Tuberculosis-resistant transgenic cattle.
نویسندگان
چکیده
Tuberculosis (TB) is a devastating disease that affects humans and many animal species. In humans, TB is mainly caused by Mycobacterium tuberculosis, whereas most cases in cattle are caused by Mycobacterium bovis. However, M. bovis can also cause, albeit rarely, human TB. In PNAS, Wu et al. (1) report the use of novel genetic tools to demonstrate that insertion of one gene into a genomic “safe harbor” can dramatically decrease pathogen replication and disease pathology in M. bovis-infected cattle, and greatly diminish transmission of the disease within cow herds. Could this be a useful approach to diminish TB in cattle and potentially humans?
منابع مشابه
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 112 13 شماره
صفحات -
تاریخ انتشار 2015